Free Access
Reprod. Nutr. Dev.
Volume 46, Number 5, September-October 2006
5th annual INRA-Meeting: Mammary gland and milk
Page(s) 579 - 588
Published online 23 September 2006
Reprod. Nutr. Dev. 46 (2006) 579-588
DOI: 10.1051/rnd:2006029

Preparation of recombinant proteins in milk to improve human and animal health

Eric Solera, Dominique Thépotb, Sylvie Rival-Gervierb, Geneviève Jolivetb and Louis-Marie Houdebineb

a  BioProtein Technologies 63, Domaine de Vilvert, 78350, Jouy-en-Josas, France
b  UMR Biologie du Développement et Reproduction, Institut National de la Recherche Agronomique, 78352 Jouy-en-Josas, France

(Published online 23 September 2006)

Abstract - Milk is a very abundant source of proteins for animal and human consumption. Milk composition can be modified using transgenesis, including exogenous gene addition and endogenous gene inactivation. The study of milk protein genes has provided researchers with regulatory regions capable of efficiently and specifically driving the expression of foreign genes in milk. The projects underway are aimed at modifying milk composition, improving its nutritional value, reducing mammary infections, providing consumers with antipathogen proteins and preparing purified recombinant proteins for pharmaceutical use. The present paper summarises the current progress in this field.

Key words: milk / recombinant proteins / animal and human health

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© INRA, EDP Sciences 2006