Reprod. Nutr. Dev.
Volume 44, Number 6, November-December 2004
|Page(s)||599 - 608|
Incorporation of oxyphytosterols in tissues of hamsterAndré Grandgirard, Joëlle Demaison-Meloche, Catherine Cordelet and Luc Demaison
Unité de Nutrition Lipidique, INRA, 17 rue Sully, BP 86510, 21065 Dijon Cedex, France
(Received 4 June 2004; accepted 5 August 2004)
Abstract - Oxyphytosterols (OPS) were fed to hamsters, at different concentrations, in order to observe their eventual incorporation into plasma, aorta, liver, kidneys and heart. The animals receiving the very high level (2500 ppm) presented 7 -hydroxycampesterol, -epoxycampesterol, campestanetriol, 7-ketocampesterol, 7 -hydroxysitosterol, -epoxysitosterol, sitostanetriol and 7-ketositosterol in all tissues. The same compounds were observed in the tissues of animals receiving 500 ppm of OPS in their diet, but with much lower levels. In hamsters fed 100 ppm of OPS, as well as in control animals, in most cases, the only observed OPS was sitostanetriol, which seems to be difficult to eliminate from the animal.
Key words: oxyphytosterol / sitostanetriol / phytosterol / plasma / aorta / liver / kidneys / heart
Corresponding author: André Grandgirard firstname.lastname@example.org
© INRA, EDP Sciences 2005