Free Access
Reprod. Nutr. Dev.
Volume 44, Number 6, November-December 2004
Page(s) 599 - 608
Reprod. Nutr. Dev. 44 (2004) 599-608
DOI: 10.1051/rnd:2004058

Incorporation of oxyphytosterols in tissues of hamster

André Grandgirard, Joëlle Demaison-Meloche, Catherine Cordelet and Luc Demaison

Unité de Nutrition Lipidique, INRA, 17 rue Sully, BP 86510, 21065 Dijon Cedex, France

(Received 4 June 2004; accepted 5 August 2004)

Abstract - Oxyphytosterols (OPS) were fed to hamsters, at different concentrations, in order to observe their eventual incorporation into plasma, aorta, liver, kidneys and heart. The animals receiving the very high level (2500 ppm) presented 7 $\beta$-hydroxycampesterol, $\beta$-epoxycampesterol, campestanetriol, 7-ketocampesterol, 7 $\beta$-hydroxysitosterol, $\beta$-epoxysitosterol, sitostanetriol and 7-ketositosterol in all tissues. The same compounds were observed in the tissues of animals receiving 500 ppm of OPS in their diet, but with much lower levels. In hamsters fed 100 ppm of OPS, as well as in control animals, in most cases, the only observed OPS was sitostanetriol, which seems to be difficult to eliminate from the animal.

Key words: oxyphytosterol / sitostanetriol / phytosterol / plasma / aorta / liver / kidneys / heart

Corresponding author: André Grandgirard

© INRA, EDP Sciences 2005