Free Access
Reprod. Nutr. Dev.
Volume 44, Number 6, November-December 2004
Page(s) 609 - 616
Reprod. Nutr. Dev. 44 (2004) 609-616
DOI: 10.1051/rnd:2004057

Sitostanetriol is not formed in vivo from sitosterol in the rat

André Grandgirard, Lucy Martine, Pierre Juanéda and Catherine Cordelet

Unité de Nutrition Lipidique, INRA, 17 rue Sully, BP 86510, 21065 Dijon Cedex, France

(Received 21 June 2004; accepted 3 September 2004)

Abstract - In a recent study, we observed some oxyphytosterols in the plasma of healthy human subjects. This experiment was effected in order to determine if these compounds could be formed in vivo from phytosterols. Rats were fed with a high level of phytosterols (1% of the diet) and they were compared to rats deprived of phytosterols, using triglycerides purified from phytosterols. Their plasma were analysed for the main oxyphytosterols. The results show that sitostanetriol and campestanetriol were not formed in vivo from phytosterols. Their levels decreased during the experiment. The diet origin is highly probable for the compounds identified in human plasma. In particular, it seems that the sitostanetriol is eliminated very slowly from the organism.

Key words: phytosterol / oxyphytosterol / sitostanetriol / plasma

Corresponding author: André Grandgirard

© INRA, EDP Sciences 2005