Extracellular signal-regulated kinases (ERK) 1, 2 are required for luteinizing hormone (LH)-induced steroidogenesis in primary Leydig cells and control steroidogenic acute regulatory (StAR) expression
Reprod. Nutr. Dev., 45 1 (2005) 101-108
Articles citing this article
The Citing articles tool gives a list of articles citing the current article.
The citing articles come from EDP Sciences database, as well as other publishers participating in CrossRef Cited-by Linking Program. You can set up your personal account to receive an email alert each time this article is cited by a new article (see the menu on the right-hand side of the abstract page).
Cited article:
This article has been cited by the following article(s):
PRM1 modulates proliferation, apoptosis, and testosterone synthesis in bovine Leydig cells
Xin Wang, Xinqi Zhou, Tongtong Tu, Shuangshuang Cui, Xiang Meng, Yunhai Zhang, Hongyu Liu and Ning SongAnimal Reproduction Science 281 107991 (2025)
https://doi.org/10.1016/j.anireprosci.2025.107991
Trafficking of luteinizing hormone receptor directs the differential signal activation between luteinizing hormone and chorionic gonadotropin
Clara Lazzaretti, Elia Paradiso, Samantha Sperduti, Rachel R. Richardson, Carmela Perri, Riccardo Bellei, Sara D'Alessandro, Lara Baschieri, Claudia Fusco, Frederic Jean-Alphonse, Eric Reiter, Monica Lispi, Manuela Simoni, Aylin C. Hanyaloglu and Livio CasariniInternational Journal of Biological Macromolecules 318 145247 (2025)
https://doi.org/10.1016/j.ijbiomac.2025.145247
Luteinizing Hormone Regulates Testosterone Production, Leydig Cell Proliferation, Differentiation, and Circadian Rhythm During Spermatogenesis
Tian Lei, Yu Yang and Wan-Xi YangInternational Journal of Molecular Sciences 26 (8) 3548 (2025)
https://doi.org/10.3390/ijms26083548
Pharmacogenomic of LH and its receptor: are we ready for clinical practice?
Alessandro Conforti, Raffaella Di Girolamo, Maurizio Guida, Carlo Alviggi and Livio CasariniReproductive Biology and Endocrinology 23 (S1) (2025)
https://doi.org/10.1186/s12958-025-01359-2
Clinical Research Progress on Dan Zhi Xiao Yao San in the Treatment of Polycystic Ovary Syndrome
思源 张Advances in Clinical Medicine 15 (11) 104 (2025)
https://doi.org/10.12677/acm.2025.15113072
Hormones and Signaling Pathways Involved in the Stimulation of Leydig Cell Steroidogenesis
Karine de Mattos, Kenley Joule Pierre and Jacques J. TremblayEndocrines 4 (3) 573 (2023)
https://doi.org/10.3390/endocrines4030041
Male infertility and gonadotropin treatment: What can we learn from real-world data?
Sandro C. Esteves, Arnold P.P. Achermann, Manuela Simoni, Daniele Santi and Livio CasariniBest Practice & Research Clinical Obstetrics & Gynaecology 86 102310 (2023)
https://doi.org/10.1016/j.bpobgyn.2022.102310
A Possible Mechanism for Double-Yolked Eggs in the Early Stage of Egg-Laying in Zhedong White Goose–Function of IGF1 and LHR Signaling
Jie Liu, Xingfei Zhao, Zichun Dai, Pengxia Yang, Rong Chen, Binbin Guo, Mingming Lei and Zhendan ShiAnimals 12 (21) 2964 (2022)
https://doi.org/10.3390/ani12212964
Association of Insulin Resistance and Elevated Androgen Levels with Polycystic Ovarian Syndrome (PCOS): A Review of Literature
Yalan Xu, Jie Qiao and Enas AbdulhayJournal of Healthcare Engineering 2022 1 (2022)
https://doi.org/10.1155/2022/9240569
Regulation of antral follicular growth by an interplay between gonadotropins and their receptors
Livio Casarini, Elia Paradiso, Clara Lazzaretti, Sara D’Alessandro, Neena Roy, Elisa Mascolo, Kornelia Zaręba, Alejandra García-Gasca and Manuela SimoniJournal of Assisted Reproduction and Genetics 39 (4) 893 (2022)
https://doi.org/10.1007/s10815-022-02456-6
Polycystic ovary syndrome and obesity: a modern paradigm
Marina B. Khamoshina, Yulia S. Artemenko, Ayshan A. Bayramova, Valentina A. Ryabova and Mekan R. OrazovRUDN Journal of Medicine 26 (4) 382 (2022)
https://doi.org/10.22363/2313-0245-2022-26-4-382-395
The Urokinase-Type Plasminogen Activator Contributes to cAMP-Induced Steroidogenesis in MA-10 Leydig Cells
Zoheir B. Demmouche and Jacques J. TremblayEndocrines 3 (3) 460 (2022)
https://doi.org/10.3390/endocrines3030037
Inhibition of testosterone synthesis induced by oral TiO2 NPs is associated with ROS-MAPK(ERK1/2)-StAR signaling pathway in SD rat
Shanji Liu, Yizhou Tang, Bolu Chen, Yu Zhao, Zoraida P Aguilar, Xueying Tao and Hengyi XuToxicology Research 10 (4) 937 (2021)
https://doi.org/10.1093/toxres/tfab077
Triiodothyronine stimulates steroid and VEGF production in murine Leydig cells via cAMP‐PKA pathway
Bodhana Dhole, Surabhi Gupta and Anand KumarAndrologia 53 (3) (2021)
https://doi.org/10.1111/and.13972
Pentachloronitrobenzene alters progesterone production and primordial follicle recruitment in cultured granulosa cells and rat ovary†
Yanrong Kuai, Xiaobo Gao, Huixia Yang, et al.Biology of Reproduction 102 (2) 511 (2020)
https://doi.org/10.1093/biolre/ioz195
Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity
Xin Zeng, Yuan-jie Xie, Ya-ting Liu, Shuang-lian Long and Zhong-cheng MoClinica Chimica Acta 502 214 (2020)
https://doi.org/10.1016/j.cca.2019.11.003
Brain‐derived neurotrophic factor: A steroidogenic regulator of Leydig cells
Shan Gao, Shuxiong Chen, Lu Chen, Yun Zhao, Liting Sun, Maosheng Cao, Yuwen Huang, Qiaoge Niu, Fengge Wang, Chenfeng Yuan, Chunjin Li and Xu ZhouJournal of Cellular Physiology 234 (8) 14058 (2019)
https://doi.org/10.1002/jcp.28095
Cardiotonic steroid ouabain stimulates steroidogenesis in Leydig cells via the α3 isoform of the sodium pump
Neha Upmanyu, Raimund Dietze, Ahmed Bulldan and Georgios Scheiner-BobisThe Journal of Steroid Biochemistry and Molecular Biology 191 105372 (2019)
https://doi.org/10.1016/j.jsbmb.2019.04.021
Gossypol Induces Disruption of Spermatogenesis and Steroidogenesis in Male Mice
Whasun Lim, Jiyeon Ham, Sunwoo Park, Hyocheol Bae, Seungkwon You and Gwonhwa SongJournal of Agricultural and Food Chemistry 67 (7) 2075 (2019)
https://doi.org/10.1021/acs.jafc.8b06946
Raf‐ERK1/2 signalling pathways mediate steroid hormone synthesis in bovine ovarian granulosa cells
Dejun Xu, Huanshan He, Xiaohan Jiang, Lulu Yang, Dinbang Liu, Li Yang, Guoxia Geng, Jianyong Cheng, Huali Chen, Rongmao Hua, Jiaxin Duan, Xiaoya Li, Lin Wu, Yuan Li and Qingwang LiReproduction in Domestic Animals 54 (5) 741 (2019)
https://doi.org/10.1111/rda.13419
Two Hormones for One Receptor: Evolution, Biochemistry, Actions, and Pathophysiology of LH and hCG
Livio Casarini, Daniele Santi, Giulia Brigante and Manuela SimoniEndocrine Reviews 39 (5) 549 (2018)
https://doi.org/10.1210/er.2018-00065
The role of mitogen-activated protein kinase–extracellular receptor kinase pathway in female fertility outcomes: a focus on pituitary gonadotropins regulation
Samira Kahnamouyi, Mohammad Nouri, Laya Farzadi, Masoud Darabi, Vahid Hosseini and Amir MehdizadehTherapeutic Advances in Endocrinology and Metabolism 9 (7) 209 (2018)
https://doi.org/10.1177/2042018818772775
Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro
Lei Shi, Ruigao Song, Xiaolei Yao and Youshe RenTheriogenology 93 24 (2017)
https://doi.org/10.1016/j.theriogenology.2017.01.022
An immortalized steroidogenic goat granulosa cell line as a model system to study the effect of the endoplasmic reticulum (ER)-stress response on steroidogenesis
Diqi YANG, Lei WANG, Pengfei LIN, et al.Journal of Reproduction and Development 63 (1) 27 (2017)
https://doi.org/10.1262/jrd.2016-111
Expression of adenosine 5′-monophosphate—Activated protein kinase (AMPK) in ovine testis (Ovis aries): In vivo regulation by nutritional state
N. Taibi, J. Dupont, Z. Bouguermouh, P. Froment, C. Ramé, A. Anane, Z. Amirat and F. KhammarAnimal Reproduction Science 178 9 (2017)
https://doi.org/10.1016/j.anireprosci.2017.01.003
Establishment and evaluation of a stable steroidogenic goat Leydig cell line
Jinhua Zhou, Rui Dai, Lanjie Lei, Pengfei Lin, Xiaolong Lu, Xiangguo Wang, Keqiong Tang, Aihua Wang and Yaping JinAnimal Science Journal 87 (4) 492 (2016)
https://doi.org/10.1111/asj.12454
Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis
Mohammed Akli Ayoub, Romain Yvinec, Gwenhaël Jégot, James A. Dias, Sonia-Maria Poli, Anne Poupon, Pascale Crépieux and Eric ReiterMolecular and Cellular Endocrinology 436 10 (2016)
https://doi.org/10.1016/j.mce.2016.07.013
Role of Protein Phosphorylation and Tyrosine Phosphatases in the Adrenal Regulation of Steroid Synthesis and Mitochondrial Function
Cristina Paz, Fabiana Cornejo Maciel, Alejandra Gorostizaga, et al.Frontiers in Endocrinology 7 (2016)
https://doi.org/10.3389/fendo.2016.00060
TNP1 Functional SNPs in bta-miR-532 and bta-miR-204 Target Sites Are Associated with Semen Quality Traits in Chinese Holstein Bulls1
Shuai Zhang, Yan Zhang, Chunhong Yang, et al.Biology of Reproduction 92 (6) (2015)
https://doi.org/10.1095/biolreprod.114.126672
Orexin A-mediated stimulation of 3β-HSD expression and testosterone production through MAPK signaling pathways in primary rat Leydig cells
D. Zheng, Y. Zhao, Y. Shen, et al.Journal of Endocrinological Investigation 37 (3) 285 (2014)
https://doi.org/10.1007/s40618-013-0035-8
FSHR polymorphism p.N680S mediates different responses to FSH in vitro
Livio Casarini, Valeria Moriondo, Marco Marino, Francesca Adversi, Francesco Capodanno, Chiarina Grisolia, Antonio La Marca, Giovanni Battista La Sala and Manuela SimoniMolecular and Cellular Endocrinology 393 (1-2) 83 (2014)
https://doi.org/10.1016/j.mce.2014.06.013
Modified high-density lipoprotein modulates aldosterone release through scavenger receptors via extra cellular signal-regulated kinase and Janus kinase-dependent pathways
Sarama Saha, Juergen Graessler, Peter E. H. Schwarz, et al.Molecular and Cellular Biochemistry 366 (1-2) 1 (2012)
https://doi.org/10.1007/s11010-012-1274-2
Involvement of IGF-I signaling pathway in the regulation of steroidogenesis in mouse Leydig cells treated with fenvalerate
Jian-Hua Qu, Juan Fei, Xia Hong, Jian-Feng Chen, Ai-Hua Gu, Hong Sun, Xiao-Lin Xu, Ling Song, Shou-Lin Wang and Xin-Ru WangToxicology 292 (2-3) 151 (2012)
https://doi.org/10.1016/j.tox.2011.12.007
Adiponectin (15–36) stimulates steroidogenic acute regulatory (StAR) protein expression and cortisol production in human adrenocortical cells: Role of AMPK and MAPK kinase pathways
Manjunath Ramanjaneya, Alex C. Conner, James E.P. Brown, et al.Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813 (5) 802 (2011)
https://doi.org/10.1016/j.bbamcr.2011.02.010
Gonadotropin-releasing hormone positively regulates steroidogenesis via extracellular signal-regulated kinase in rat Leydig cells
Bing Yao, Hai-Yan Liu, Yu-Chun Gu, et al.Asian Journal of Andrology 13 (3) 438 (2011)
https://doi.org/10.1038/aja.2010.158
The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA‐10Mouse Leydig Tumor Cells
Bo-Syong Pan, Chun-Yu Lin and Bu-Miin HuangEvidence-Based Complementary and Alternative Medicine 2011 (1) (2011)
https://doi.org/10.1155/2011/750468
The Role of Specific Mitogen-Activated Protein Kinase Signaling Cascades in the Regulation of Steroidogenesis
Pulak R. Manna and Douglas M. StoccoJournal of Signal Transduction 2011 1 (2011)
https://doi.org/10.1155/2011/821615
48 (2009)
https://doi.org/10.1017/CBO9780511635656.005
Hormonal activation of a kinase cascade localized at the mitochondria is required for StAR protein activity
Cecilia Poderoso, Paula Maloberti, Alejandra Duarte, et al.Molecular and Cellular Endocrinology 300 (1-2) 37 (2009)
https://doi.org/10.1016/j.mce.2008.10.009
Development of an in vitro reproductive screening assay for novel pharmaceutical compounds
Vicki Edwards, Elda Markovic, Janis Matisons and Fiona YoungBiotechnology and Applied Biochemistry 51 (2) 63 (2008)
https://doi.org/10.1042/BA20070223
The Src tyrosine kinase pathway regulates thecal CYP17 expression and androstenedione secretion
Gaurav Chaturvedi, Koji Arai, Paul F. Terranova and Katherine F. RobyMolecular and Cellular Biochemistry 318 (1-2) 191 (2008)
https://doi.org/10.1007/s11010-008-9871-9
VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues
Tae-Hong Kang and Kyong-Tai KimBiochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783 (1) 49 (2008)
https://doi.org/10.1016/j.bbamcr.2007.10.011
Orexins Stimulate Steroidogenic Acute Regulatory Protein Expression through Multiple Signaling Pathways in Human Adrenal H295R Cells
Harpal S. Randeva, Peter R. Stanfield, Jing Chen, Alex C. Conner and Manjunath RamanjaneyaEndocrinology 149 (8) 4106 (2008)
https://doi.org/10.1210/en.2007-1739
Molecular Mechanisms of Insulin-like Growth Factor-I Mediated Regulation of the Steroidogenic Acute Regulatory Protein in Mouse Leydig Cells
Pulak R. Manna, Syam P. Chandrala, Steven R. King, et al.Molecular Endocrinology 20 (2) 362 (2006)
https://doi.org/10.1210/me.2004-0526