Free Access
Reprod. Nutr. Dev.
Volume 42, Number 4, July-August 2002
Page(s) 339 - 354


  1. Argenzio R.A., Liacos J.A., Levy M.L., Meuten D.J., Lecce J.G., Powell D.W., Villous atrophy, crypt hyperplasia, cellular infiltration, and impaired glucose-Na absorption in enteric cryptosporidiosis of pigs, Gastroenterology 98 (1990) 1129-1140.
  2. Brooks P.H., Moran C.A., Beal J.D., Demeckova V., Campbell A., Liquid feeding for the young piglet, in: Varley M.A., Wiseman J. (Eds.), The Weaner Pig. Nutrition and Management, CAB International, Wallingford, UK, 2001, pp. 151-178.
  3. Bruininx E.M., Van der Peet-Schwering C.M.C., Schrama J.W., Individual feed intake of group-housed weaned pigs and health status, in: Varley M.A.,Wiseman J. (Eds.), The Weaner Pig. Nutrition and Management, CAB International, Wallingford, UK, 2001, pp. 113-122.
  4. Castillo R.O., Feng J.J., Stevenson D.K., Kerner J.A., Kwong LK., Regulation of intestinal ontogeny by intraluminal nutrients, J. Pediatr. Gastroenterol. Nutr. 10 (1990) 199-205.
  5. Cera K.R., Mahan D.C., Cross R.F., Reinhart G.A., Whitmoyer R.E., Effect of age, weaning and postweaning diet on small intestinal growth and jejunal morphology in young swine, J. Anim. Sci. 66 (1988) 574-584.
  6. Cera K.R., Mahan D.C., Reinhart G.A., Effect of weaning, week postweaning and diet composition on pancreatic and small intestinal luminal lipase response in young swine, J. Anim. Sci. 68 (1990) 384-391.
  7. Chen S.C., Shen T.F., Jiang Y.N., Chen S.Y., Effect of protein source and days after weaning on the development of digestive capacity in weaning pigs. 1. Weight of digestive tissues, J. Chin. Soc. Anim. Sci. 21 (1992) 113-122.
  8. Dréau D., Lallès J.P., Philouze-Romé V., Toullec R., Salmon H., Local and systemic immune responses to soybean protein ingestion in early-weaned pigs, J. Anim. Sci. 72 (1994) 2090-2098.
  9. Dunsford B.R., Knabe D.A., Haensly W.E., Effect of dietary soybean meal on the microscopic anatomy of the small intestine in the early-weaned pig, J. Anim. Sci. 67 (1989) 1855-1863.
  10. Efird R.C., Armstrong W.D., Herman D.L., The development of digestive capacity in young pigs: effects of age and weaning system, J. Anim. Sci. 55 (1982) 1380-1387.
  11. Gaskins H.R., Immunological aspects of the host/microbia interactions at the intestinal epithelium, in: Mackie R., White B.A., Isaacson R.E. (Eds.), Gastrointestinal Microbiology, Chapmann and Hall, New York, 1997, p. 537.
  12. Goodlad R.A., Wright N.A, The effects of starvation and refeeding on intestinal cell proliferation in the mouse, Virchows Arch. B Cell Pathol. 45 (1984) 63-73.
  13. Goodlad R.A., Levi S., Lee C.Y., Mandir N., Hodgson H., Wright N.A., Morphometry and cell proliferation in endoscopic biopsies: evaluation of a technique, Gastroenterology 101 (1991) 1235-1241.
  14. Hall G.A., Byrne T.F., Effects of age and diet on small intestinal structure and function in gnotobiotic piglets, Res. Vet. Sci. 47 (1989) 387-392.
  15. Hampson D.J., Attempts to modify changes in the piglet small intestine after weaning, Res. Vet. Sci. 40 (1986) 313-317.
  16. Hampson D.J., Kidder D.E., Influence of creep feeding and weaning on brush border enzyme activities in the piglet small intestine, Res. Vet. Sci. 40 (1986) 24-31.
  17. Hodin R.A., Graham J.R., Meng S., Upton M.P., Temporal pattern of rat small intestinal gene expression with refeeding, Am. J. Physiol. 266 (1994) G83-G89.
  18. Kelly D., Colostrum, growth factors and intestinal development in pigs, in: Souffrant W.B., Hagemeister H. (Eds.), The VIth International Symposium on Digestive Physiology in Pigs, EAAP Publication no. 80, Dummerstorf, Bad Doberan, 1994, pp. 151-166.
  19. Kelly D., Smyth J.A., McCracken K.J., Digestive development of the early-weaned pig. 1. Effect of continuous nutrient supply on the development of the digestive tract and on changes in digestive enzyme activity during the first week post-weaning, Br. J. Nutr. 65 (1991) 169-180.
  20. Kelly D., Smyth J.A., McCracken K.J., Digestive development of the early-weaned pig. 2. Effect of level of food intake on digestive enzyme activity during the immediate post-weaning period, Br. J. Nutr. 65 (1991) 181-188.
  21. Kidder D.E., Manners M.J., The level of distribution of carbohydrases in the small intestine mucosa of pigs from 3 weeks of age to maturity, Br. J. Nutr. 43 (1980) 141-153.
  22. Le Dividich J., Esnault T., Lynch B., Hoo-Paris R., Castex C., Peiniau J., Effect of colostral fat level on fat deposition and plasma metabolites in the newborn pig, J. Anim. Sci. 69 (1991) 2480-2488.
  23. Le Dividich J., Sève B., Effects of underfeeding during the weaning period on growth, metabolism, and hormonal adjustments in the piglet, Domest. Anim. Endocrinol. 19 (2000) 63-74.
  24. Legault C., Génétique et prolificité des truies: la voie hyperprolifique et la voie sino-européenne, INRA Prod. Anim. 11 (1998) 214-218.
  25. Li D.F., Nelssen J.L., Reddy P.G., Blecha F., Hancock J.D., Allee G.L., Goodband R.D., Klemm R.D., Transient hypersensitivity to soybean meal in the early-weaned pig, J. Anim. Sci. 68 (1990) 1790-1799.
  26. Makkink C.A., Negulescu G.P., Qin G., Verstegen M.W., Effect of dietary protein source on feed intake, growth, pancreatic enzyme activities and jejunal morphology in newly-weaned piglets, Br. J. Nutr. 72 (1994) 353-368.
  27. McCracken B.A., Gaskins H.R., Ruwe-Kaiser P.J., Klasing K.C., Jewell D.E., Diet-dependent and diet-independent metabolic responses underlie growth stasis of pigs at weaning, J. Nutr. 125 (1995) 2838-2845.
  28. McCracken B.A., Spurlock M.E., Roos M.A., Zuckermann F.A., Gaskins H.R., Weaning anorexia may contribute to local inflammation in the piglet small intestine, J. Nutr. 129 (1999) 613-619.
  29. Mosenthin R., Physiology of small and large intestine of swine - Review, Asian-Australas. J. Anim. Sci. 11 (1998) 608-619.
  30. Nabuurs M.J., Hoogendoorn A., van der Molen E.J., van Osta A.L., Villus height and crypt depth in weaned and unweaned pigs, reared under various circumstances in The Netherlands, Res. Vet. Sci. 55 (1993) 78-84.
  31. NRC, Nutrient Requirements of Swine, National Academy Press, Washington, DC, 1988.
  32. Orgeur P., Salaün C., Le Roux T., Venturi E., Le Dividich J., L'adoption et le sevrage ultra- précoce : une stratégie pour élever les porcelets en surnombre, in: 32 $^{{\rm es}}$ Journées de la Recherches Porcine en France, Paris, 2000, pp. 14-149.
  33. Pluske J.R., Williams I.H., Aherne F.X., Nutrition of the neonatal pig, in: Varley M.A. (Ed.), The Neonatal Pig. Development and survival, CAB International, Wallingford, UK, 1995, pp. 187-235.
  34. Pluske J.R., Williams I.H., Aherne F.X., Villous height and crypt depth in piglets in response to increases in the intake of cows' milk after weaning, Anim. Sci. 62 (1996) 145-158.
  35. Pluske J.R., Williams I.H., Aherne F.X., Maintenance of villous height and crypt depth in piglets by providing continuous nutrition after weaning, Anim. Sci. 62 (1996) 131-144.
  36. Pluske J.R., Hampson D.J., Williams I.H., Factors influencing the structure and function of the small intestine in the weaned pig: a review, Livest. Prod. Sci. 51 (1997) 215-236.
  37. Puchal A.A., Buddington R.K., Postnatal development of monosaccharide transport in pig intestine, Am. J. Physiol. (1992) G895-G902.
  38. Report of the Scientific Veterinary Committee of Animal Welfare Section, `The welfare of intensively kept pigs', Doc XXIV/B3/Sc VC/005/ 1997 final, 1997 September 30th.
  39. Rudo N.D., Rosenberg I.R., Wissler R.W., The effect of partial starvation and glucagon treatment on intestinal villus morphology and cell migration, Proc. Soc. Exp. Biol. Med. 152 (1976) 277-280.
  40. SAS, SAS user's guide: statistics, SAS Inst Inc, Cary, NC, 1990.
  41. Sève B., Reeds P.J., Fuller M.F., Cadenhead A., Hay S.M., Protein synthesis and retention in some tissues of the young pig as influenced by dietary protein intake after early-weaning. Possible connection to the energy metabolism, Reprod. Nutr. Dev. 26 (1986) 849-861.
  42. Spreeuwenberg M.J., Verdonk J.M., Gaskins H.R., Verstegen M.W, Small intestine epithelial barrier function is compromised in pigs with low feed intake at weaning, J. Nutr. 131 (2001) 1520-1527.
  43. Stoll B., Chang X., Fan M.Z., Reeds P.J., Burrin D.G., Enteral nutrient intake level determines intestinal protein synthesis and accretion rates in neonatal pigs, Am. J. Physiol. 279 (2000) G288-G294.
  44. Tang M., Laarveld B., Van Kessel A.G., Hamilton D.L., Estrada A., Patience J.F., Effect of segregated early weaning on postweaning small intestinal development in pigs, J. Anim. Sci. 77 (1999) 3191-3200.
  45. Tarvid I., Cranwell P.D., Ma L., Vavala R., The early postnatal development of protein digestion in pigs. II. Small intestinal enzymes, in: Souffrant W.B., Hagemeister H. (Eds.), The Vith International Symposium on Digestive Physiology in Pigs. EAAP Publication no. 80, Dummerstorf, Bad Doberan, 1994, pp. 181-184.
  46. van Beers-Schreurs H.M., Vellenga L., Wensing T., Breukink H.J., The pathogenesis of the post-weaning syndrome in weaned piglets: A review, Vet. Q. 14 (1992) 29-33.
  47. van Beers-Schreurs H.M., Nabuurs M.J., Vellenga L., van der Kalsbeek V., Wensing T., Breukink H.J., Weaning and the weanling diet influence the villous height and crypt depth in the small intestine of pigs and alter the concentrations of short-chain fatty acids in the large intestine and blood, J. Nutr. 128 (1998) 947-953.
  48. Wu G., Meier S.A., Knabe D.A., Dietary glutamine supplementation prevents jejunal atrophy in weaned pigs, J. Nutr. 126 (1996) 2578-2584.
  49. Zijlstra R.T., Whang K.Y., Easter R.A., Odle J., Effect of feeding a milk replacer to early-weaned pigs on growth, body composition, and small intestinal morphology, compared with suckled littermates, J. Anim. Sci. 74 (1996) 2948-2959.


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