Issue |
Reprod. Nutr. Dev.
Volume 46, Number 5, September-October 2006
5th annual INRA-Meeting: Mammary gland and milk
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Page(s) | 515 - 525 | |
DOI | https://doi.org/10.1051/rnd:2006033 | |
Published online | 23 September 2006 |
DOI: 10.1051/rnd:2006033
The retina is more susceptible than the brain and the liver to the incorporation of trans isomers of DHA in rats consuming trans isomers of alpha-linolenic acid
Niyazi Acara, b, Brigitte Bonhommec, Corinne Joffrea, b, Alain M. Brond, b, Catherine Creuzot-Garcherd, b, Lionel Bretillona, b, Michel Dolyc and Jean-Michel Chardignya, ea INRA, Lipid Nutrition Unit, 17, rue Sully, BP86510, Dijon Cedex, 21065 France
b Current affiliation: INRA, UMR FLAVIC, Eye and Nutrition Research Group, 17 rue Sully, BP 86510, Dijon Cedex, 21065 France
c Laboratory of Biophysics, School of Pharmacy, University of Auvergne, UPRES - EA 2667, 28 place Henri Dunant, BP38, Clermont-Ferrand, 63001 France
d Department of Ophthalmology, University Hospital, 3 rue du Faubourg Raines, BP 519, Dijon, 21033 France
e Current affiliation: INRA, UMR1019, Équipe MLE, Clermont-Ferrand, CRNH Auvergne, Clermont-Ferrand, 63009 France
(Published online 23 September 2006)
Abstract - Trans polyunsaturated fatty acids are formed during heat
treatments of vegetable oils from polyunsaturated fatty acids containing
cis double bonds. After dietary intake, they are distributed in the body and
are incorporated into nervous tissues including the retina. Since nervous
tissues are known to be rich in n-3 fatty acids such as docosahexaenoic acid
(DHA), we studied the ability of the retina and the brain to incorporate
trans isomers of DHA formed in vivo from the dietary precursor trans -linolenic
acid. Wistar rats were fed with trans isomers of
-linolenic acid for 21
months. A linear incorporation of trans DHA and a decrease in cis DHA was observed
in the retina, whereas no major changes were observed in the brain. In
parallel to the modifications in retinal cis and trans DHA levels, the retinal
functionality evaluated by the electroretinogram showed defects in animals
that consumed trans
-linolenic acid. These results suggest that the
mechanisms leading to the incorporation of cis and trans fatty acids are quite
different in the retina when compared to the brain and the liver, the retina
being more susceptible to changes in the dietary lipid contribution.
Key words: dietary trans polyunsaturated fatty acids / rat / retina / cerebral cortex / electroretinography
Corresponding author: acar@dijon.inra.fr
© INRA, EDP Sciences 2006