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Issue
Reprod. Nutr. Dev.
Volume 45, Number 3, May-June 2005
SYMPOSIUM: Homage to Professor Charles Thibault
Page(s) 377 - 382
DOI https://doi.org/10.1051/rnd:2005028
Reprod. Nutr. Dev. 45 (2005) 377-382
DOI: 10.1051/rnd:2005028

Foxl2 gene and the development of the ovary: a story about goat, mouse, fish and woman

Daniel Barona, Frank Batistab, Stéphane Chaffauxc, Julie Cocquetb, Corinne Cotinotd, Edmond Cribiuc, Elfride De Baereee, Yann Guiguena, Francis Jaubertb, Eric Pailhouxd, Maëlle Pannetierd, Daniel Vaimanb, Bernard Vigierd, Reiner Veitiab and Marc Fellousb

a  Équipe Sexualité et Reproduction, INRA-SCRIBE, Département PHASE, Campus de Beaulieu, 35042 Rennes Cedex, France
b  INSERM U709, Pavillon Baudelocque, 123, Boulevard de Port Royal, 75014 Paris, France
c  Laboratoire de Génétique Biochimique et Cytogénétique, Domaine du Vilvert Centre INRA, 78350 Jouy-en-Josas, France
d  UMR Biologie du Développement et Reproduction, Domaine du Vilvert Centre INRA, 78350 Jouy-en-Josas, France
e  University of Gand, Belgium

Abstract - In this review, we describe recent results concerning the genetics of sex determination in mammals. Particularly, we developed the study of the FOXL2 gene and its implication in genetic anomalies in goats (PIS mutation) and humans (BPES). We present the expression of FOXL2 in the ovaries of different species.


Key words: ovary / comparative genomics / FOXL2 / PIS / BPES

Corresponding author: Marc Fellous ellous@cochin.inserm.fr

© INRA, EDP Sciences 2005