Free Access
Reprod. Nutr. Dev.
Volume 42, Number 4, July-August 2002
Page(s) 307 - 316
Reprod. Nutr. Dev. 42 (2002) 307-316
DOI: 10.1051/rnd:2002027

Influence of lipoic acid on lipid metabolism and $\beta$-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens

Yoshio Hamano

Department of Animal Science, Akita Prefectural College of Agriculture, Ohgata 010 0444, Japan
(Received 14 September 2001; accepted 31 May 2002)

The effects of lipoic acid (LA) on muscle growth, metabolic response and hepatic respiration in broilers treated with or without clenbuterol (CLE) were examined. In 4-week-old chickens, dietary LA administration (100 mg $\cdot$kg -1) enhanced the $\beta$-adrenergic response of plasma nonesterified fatty acid with an intravenous injection of CLE (50 $\mu$g $\cdot$kg -1, estimated from the response area for 120 min (-7860 vs. 874 $\mu$mol $\cdot$L $^{-1}\cdot$min in control and LA-treated groups, respectively; P < 0.05). When chickens received long-term oral administration of CLE (0.25 mg $\cdot$kg -1) for 30 d, LA interfered with the repartitioning action of CLE, decreased abdominal fat weight ( P < 0.05) and increased protein concentration of the breast muscle ( P < 0.05), in 7-week-old chickens. In addition, the LA supplementation alone increased both plasma nonesterified fatty acid ( P < 0.05) and triacylglycerol ( P < 0.05), whereas these effects were not associated with CLE administration. These findings suggest that the dietary LA level used stimulates rapid lipolytic response of plasma nonesterified fatty acid to CLE injection and fatty acid turnover between adipose tissue and the liver, but does not facilitate the repartitioning action of CLE during long-term treatment in broilers.

Key words: lipoic acid / clenbuterol / triacylglycerol / lipolysis / chicken

Correspondence and reprints: Yoshio Hamano

© INRA, EDP Sciences 2002